Erbi Biosystems, a part of MilliporeSigma

Erbi Biosystems is revolutionizing cell therapy and bioprocessing process development with the Breez™, a fully automated 2 mL TruePerfusion™ bioreactor. Scarce and expensive raw materials no longer restrict generation of process development data enabling improved CMC. A single 2mL volume cassette can deliver up to 400M (CHO and T-cells), sufficient for most development needs and a number of CAR-T clinical dose regimes. The platform offers a 90% footprint reduction using disposable, functionally closed single-use cassettes with proprietary microfluidic technology processes capable of performing activation, transduction, intensified growth, and diafiltration steps. It offers closed-loop control of pH, total cell density (OD), dissolved oxygen, and CO2 measurements. The integrated online sensors and intuitive software deliver sophisticated feeding strategies, increased cell concentration, low shear, bubble-free mixing with high kLa resulting in performance far exceeding the static and benchtop reactors typically used today.