Jonathan Chernoff

Researcher

I have devoted my research career to understanding how cells receive and interpret signals, and how this process in corrupted in cancer. In particular, I have focused on the regulation of signal transduction by phosphorylation. My overarching goal is the understanding of mechanisms underlying how signal transduction pathways are rewired in cancer, and their implications for the development, spread, and resistance of solid tumors to therapy. My group has made important discoveries in three signaling pathways: Rho-family small GTPases, Hippo, and Insulin signaling, through discoveries and subsequent work on the STE20 kinases Pak and Mst, and the protein tyrosine phosphatase PTP1B, respectively, as detailed below. I have been continuously funded by the NIH (NCI and/or GM) since 1992, and during this time, our group has developed broad expertise in molecular biology, biochemistry, cell biology, proteomics, and mouse models of cancer. For the last decade, I have been part of the leadership team at Fox Chase, first as Scientific Director/Deputy Director and now as Cancer Center Director.

Talks About
#chemistry #biology #molecular

Preferred Locations
#Northamerica